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KMID : 1007520230320111541
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Food Science and Biotechnology
2023 Volume.32 No. 11 p.1541 ~ p.1549
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Untargeted metabolite profiling of serum in rats exposed to pyrraline
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Chuanqin Hu
Jiahui Wang
Fangyuan Qi
Yingli Liu
Fen Zhao
Jing Wang
Seo Jung-Yeol
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Abstract
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Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.
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KEYWORD
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Mass spectrometry (MS), Food safety, Metabolomic, Untargeted metabolite profiling, Pyrraline
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